Authors response on Klebsiella pneumoniae, producer of carbapenemases
نویسندگان
چکیده
منابع مشابه
A structural, epidemiological & genetic overview of Klebsiella pneumoniae carbapenemases (KPCs)
Klebsiella pneumoniae carbapenemases (KPCs) are plasmid encoded carbapenem hydrolyzing enzymes which have the potential to spread widely through gene transfer. The instability of upstream region of blaKPC accelerates emergence of different isoforms. Routine antibiotic susceptibility testing failed to detect KPC producers and some commercial kits have been launched for early identification of KP...
متن کاملSpecimen #1, Urine Culture: Klebsiella pneumoniae; carbapenemase producer
Intended Goal: The isolate in this specimen was a carbapenemase-producing Klebsiella pneumoniae with resistance mediated by the blaKPC. It was chosen to emphasize the urgent infection control and prevention situation that these organisms present when identified. It was also chosen to illustrate the challenges laboratorians face with the ever-changing antimicrobial susceptibility testing (AST) b...
متن کاملThe spread of Klebsiella pneumoniae carbapenemases: a tale of strains, plasmids, and transposons.
Carbapenemases are a large and diverse family of microbial enzymes that hydrolyze not only carbapenems but also other b-lactams, with the occasional exception of monobactams, such as aztreonam. For clinicians, the nomenclature of carbapenemases, like that of other b-lactamases, is confusing. In keeping with other b-lactamases, carbapenemases can be classified on the basis of function or structu...
متن کاملOverview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance
Klebsiella pneumoniae carbapenemases (KPCs) confer resistance to nearly all β-lactams. This broad-spectrum drug resistance mechanism has rapidly spread in the United States and is reportedly increasing elsewhere in the world. Thus, the emergence of KPC resistance is a major threat to global health. This article reviews the epidemiology and provides an overview of the dissemination of KPC-produc...
متن کاملEmergence of Klebsiella pneumoniae Coharboring KPC and VIM Carbapenemases in Colombia.
Klebsiella pneumoniae strains coharboring KPC and VIM carbapenemases have been reported, to the best of our knowledge, only in Greece (1–5) and Germany (6). The coexpression of these two resistance determinants poses a major threat to antibiotic utility worldwide. Herein we report, for the first time in the Americas, a K. pneumoniae isolate harboring blaKPC and blaVIM genes. In September 2010, ...
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ژورنال
عنوان ژورنال: Medwave
سال: 2018
ISSN: 0717-6384
DOI: 10.5867/medwave.2018.03.7223